Question regarding Imaginary and the "File Support" options

I am using Imaginary on my Nextcloud instance; in the File Support section of the options it mentions ignoring that section if using Imaginary.

My question is, since I’m using Imaginary is it helpful to toggle all of those to Off, or does it not matter whether they’re toggled On or Off?

Reason I’m asking is, I’m wondering if having them toggled On might cause (even if just a small) conflict, or possibly result in slower performance (with NC we all know every micro-nano-mini-millisecond counts in speed).

It shouldn’t.

Just a note: I don’t recommend Imaginary right now if you use HEIC. Your photos might be incorrectly rotated, and Imaginary can be slower than the default Imagick-based implementation