HOWTO: Create a second NC instance on the same server

I am posting here because my first instance is up and running and I have no problems with it, yet. If I should have posted in Installation, please advise or simply move my post. I have searched support questions for the last quarter in both the installation and this forum.

I learned everything I know about apache2, php, and nextcloud over the last week in the course of getting my first instance up and running. and ssllabs both rate my instance A. It was a good experience.

Short and sweet, I would like to run a completely separate instance on the same server, under apache2. Can it be done? Is there a guide? Is this basically an apache2 question? It seems as “simple” as running two virtual servers on port 443 and finding some way to segregate them by domain as various clients come in.