If you head over to NCs YouTube channel and grab the videos from this years conference, there is a video which expains this. The main consensus is this:
you can scale some components of a NC setup, e.g. HTTP-Server or MySQL
other components don’t scale that well
The main takeaway is: global scale is all about federation, where you do have many smaller local NC instances which trust each other and where you can easily find remote users, by their username@nc-instance-name. This way, you will have a decentralized, distributed cloud setup, which works around the limitations of scaling the distinct components.