AIO separate database location

I recently migrated my nextcloud vm to docker using AIO with NFS share hosted on truenas ZFS for data directory. It’s all working great, but I was hoping to move the database to a separate NFS share so I can tune them differently. Specifically I’d like a much smaller record size for the database vs larger for data dir.

Is this possible with AIO? I’ve searched quite a bit and found a few people ask but not answered.

Edit for clarity: Freenas box serving NFS shares on one box, Docker on a different box running AIO, reverse proxy, etc.