Error 500 - Failed to connect to the database: exception occurred in driver could not find driver

Although you’ve already check the list of loaded php modules, the error messages indicates that the php cli configuration seems not be configured correctly. You can e.g. test the database access using the following php test script:

<?php

#$dsn = 'mysql:dbname=nextcloud;unix_socket=/run/mysql/102/mysql.sock';
 $dsn = 'mysql:dbname=nextcloud;host=localhost:3306';
 $opt = [
     PDO::ATTR_ERRMODE            => PDO::ERRMODE_EXCEPTION,
     PDO::ATTR_DEFAULT_FETCH_MODE => PDO::FETCH_ASSOC,
     PDO::ATTR_EMULATE_PREPARES   => false,
 ];
$user = '<user>';
$pass = '<pass>';

try {
    $pdo = new PDO($dsn, $user, $pass, $opt);
    $sql = "SHOW TABLES";
    $stmt = $pdo->query($sql);

    print("-start-------------<br>\n");
    while ($row = $stmt->fetch())
    {
        $str = implode($row);
        print($str."<br>\n");
    }
    print("-end---------------<br>\n");
} catch (PDOException $e) {
    echo 'Connection failed: ' . $e->getMessage() . "\n";
}

?>