Nextcloud AIO Recommendation
The question concerns deploying Nextcloud All-in-One (AIO) on Alpine Linux. I understand the interest in alternative distributions.
While theoretically possible to run Nextcloud AIO on Alpine, Ubuntu is the recommended distribution. I run multiple Nextcloud AIO servers on Ubuntu and haven’t experienced any issues with functionality or stability.
Important Aspects for Larger Files
With Nextcloud AIO, beyond choosing the operating system, pay attention to the filesystem and swap settings, especially if you’re considering uploading larger multimedia files. My experiences testing large file synchronization with Nextcloud AIO and Nginx proxy are in this post: Testing Large File Synchronization with Nextcloud AIO and Nginx Proxy - June 2025 Update.