Upload problem with new Installation

Hello,
I’ve some problems with upload files more than 20Mb.

Php Modulues:
core mod_so mod_watchdog http_core mod_log_config mod_logio mod_version mod_unixd mod_access_compat mod_alias mod_auth_basic mod_authn_core mod_authn_file mod_authz_core mod_authz_host mod_authz_user mod_autoindex mod_deflate mod_dir mod_env mod_filter mod_headers mod_mime prefork mod_negotiation mod_php7 mod_reqtimeout mod_setenvif mod_socache_shmcb mod_ssl mod_status

php.ini config:
file_uploads On
max_file_uploads 1000
upload_max_filesize 100G
max_execution_time 3600
max_input_time -1
memory_limit 4G

I use an external Database (mysql)

Error:

Fatal webdav Doctrine\DBAL\Exception\DriverException: An exception occurred while executing ‘SELECT fileid FROM oc_filecache WHERE (storage = ?) AND (path_hash = ?)’ with params [2, “357a83e5df3dbac207c3aaf47af088fb”]: SQLSTATE[HY000]: General error: 2006 MySQL server has gone away 2020-03-02T20:56:06+0100
Error no app in context Doctrine\DBAL\Exception\DriverException: An exception occurred while executing ‘SELECT filecache.fileid, storage, path, path_hash, filecache.parent, name, mimetype, mimepart, size, mtime, storage_mtime, encrypted, etag, permissions, checksum, metadata_etag, creation_time, upload_time FROM oc_filecache filecache LEFT JOIN oc_filecache_extended fe ON filecache.fileid = fe.fileid WHERE (storage = ?) AND (path_hash = ?)’ with params [2, “45b963397aa40d4a0063e0d85e4fe7a1”]: SQLSTATE[HY000]: General error: 2006 MySQL server has gone away 2020-03-02T20:56:06+0100

How can I resolve?

Thanks
Kind Regards

Anyone?

Thanks very much