Upgrading PHP to 8.1 while Using Talk

Nextcloud version (eg, 20.0.5): 25.0.4
Operating system and version (eg, Ubuntu 20.04): 20.04
Apache or nginx version (eg, Apache 2.4.25): Apache 2.4.41
PHP version (eg, 7.4): 8.1

The issue you are facing

I am using Talk and after MANY MONTHS of pain where the server would crawl to a halt, I believe someone finally helped me understand that php-fpm needs to run with mpm_event rather than mpm_prefork. Yeah! Things seem to be working well now. However, I see that php8.1 wants to only operate with mpm_prefork. Will this work when wanting to use php_fpm moving forward? I haven’t seen anything written about this specifically yet.

What makes you think that? I’ve always run apache2 / php-fpm with mpm_event.
You could eventually optimize the process manager (pm.*) settings of your php-fpm (for ubuntu in /etc/php/8.1/fpm/pool.d/www.conf) for better performance.