Switch from microSD card to USB stick?

Nextcloud version: 25.0.5
Operating system and version: Ubuntu 22.04.2 LTS
PHP version: 8.1.17


I’m running my Nextcloud on a Raspberry Pi 4. Currently, my Nextcloud data directory is on an external HDD and my OS (Ubuntu 22.04.2 LTS), the Nextcloud itself (running on apache2) and all the other stuff are installed on a microSD card. Since this microSD card isn’t that fast and only has 20% storage left, I want to switch to an USB stick.
I’m wondering if it’s possible to clone the microSD card to an USB stick without any data loss or problems in general. Are there any risks or eventual issues?

Thank you in advance!
(sorry for eventual grammar or spelling mistakes)