Security when running from home NAS

What are the main security issues that I need to address when running NextCloud from my home NAS? I haven’t taken any specific steps to address security yet, so far I’ve installed NextCloud via Docker on my openmediavault nas.

I did go through the steps to install and setup of letsencrypt, but it looks like that is not an option for me because my ISP blocks port 80. I don’t know enough about letsencrypt to deviate from setup guides which all say I need port 80 to authorize the certificate.

if the nc client (pc/smartphone) accepts selfsigned certificates. take them.
as far as i know there are difference in encryption security matters.