No more connection from any desktop client possible

I‘m running a nextcloud server within docker (apache, mariadb, letsencrypt + reverse proxy) since nextcloud version 15. Now I‘m running latest version.
I have connected two windows clients and to mac clients, synchronization works well.
Unfortunately, now I‘m not able to connect any additional client anylonger.
After entering password and 2F auth I just have a granting access loop.
I connected my running clients with older server versions and older client versions!
Where is the problem?

After refining my google search, I‘ve found the solution:
Just had to add
“overwriteprotocol” => “https”
in my config.php.
The issue is related to the desktop client (down to version 2.5), but I don‘t know whether it is a feature or a bug!