How to manage multiple USB Devices properly (OS running on SSD plugged in by USB)

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Hi all,

I have an issue with the drive management of the NextcloudPi.

Here my desired setup:
RaspberryPi4 with a SSD running the OS. (But this is done via USB)

2 Drives, one for the Data and one for Backup.

No I have really big problems in setting it up, every time I am done with configuration (Which is by the way very easy and conveniant! :wink: ) I can not set up any further USB drives because I can not unplug the SSD and if if format a new USB drive everything ( including my OS SSD) is erased.

Do you have any suggestions how to set it up?

I want to use it as my main file system for all data. so I want it to be robust with auto Backups. And the SSD is there for speed.
I mean I could set it up using an SD card and then clone the SD card to the SSD once I’m done. but then I still can not make any changes to the USB drives.

Do you have any suggestions for me?

Thank you in advance!

Best regards,