AH0111: Config variable ${APACHE_RUN_DIR} is not defined - Nextcloud does not start

log:
[Thu Jul 08 20:55:00.521049 2021] [core:notice] [pid 1] AH00094: Command line: ‘apache2 -D FOREGROUND’

apache2 -D FOREGROUND:
[pid 42] AH0111: Config variable ${APACHE_RUN_DIR} is not defined
apache2: Syntax error on line 82 of /etc/apache2/apache2.conf: DefaultRuntimeDir must be a valid directory, absolute or relative to ServerRoot
/var/run/apache2

Nextcloud (running in a docker container) doesn’t start up.
On console:
source /etc/apache2/envvars
/usr/sbin/apache2 -V

Server version: Apache/2.4.38 (Debian)
Server built: 2020-08-25T20:08:29
Server’s Module Magic Number: 20120211:84
Server loaded: APR 1.6.5, APR-UTIL 1.6.1
Compiled using: APR 1.6.5, APR-UTIL 1.6.1
Architecture: 64-bit
Server MPM: prefork
threaded: no
forked: yes (variable process count)
Server compiled with…
-D APR_HAS_SENDFILE
-D APR_HAS_MMAP
-D APR_HAVE_IPV6 (IPv4-mapped addresses enabled)
-D APR_USE_SYSVSEM_SERIALIZE
-D APR_USE_PTHREAD_SERIALIZE
-D SINGLE_LISTEN_UNSERIALIZED_ACCEPT
-D APR_HAS_OTHER_CHILD
-D AP_HAVE_RELIABLE_PIPED_LOGS
-D DYNAMIC_MODULE_LIMIT=256
-D HTTPD_ROOT="/etc/apache2"
-D SUEXEC_BIN="/usr/lib/apache2/suexec"
-D DEFAULT_PIDLOG="/var/run/apache2.pid"
-D DEFAULT_SCOREBOARD=“logs/apache_runtime_status”
-D DEFAULT_ERRORLOG=“logs/error_log”
-D AP_TYPES_CONFIG_FILE=“mime.types”
-D SERVER_CONFIG_FILE=“apache2.conf”

I think error turned up after update for 21.0.2 → 21.0.3
But a full purge of the container and a fresh installation of 22.0.0 leads to the same error. /var/html/html was kept.